Pawr ELISA Kit for Rat(Rattus norvegicus) | EIAab.comPawr ELISA Kit for Rat(Rattus norvegicus)

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Pawr (Gene name),

PRKC apoptosis WT1 regulator protein (Protein name ), PAWR_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Pawr(Par4);

Protein name:

PRKC apoptosis WT1 regulator protein;

Alternative:

Transcriptional repressor Par-4-like protein PAWR;Prostate apoptosis response 4 protein(Par-4);

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Interacts with WT1, via the C-terminal region. Homooligomer. Interacts also with a wide variety of proteins, such as atypical PKCs, p62, DAPK3 kinase and THAP1. Interacts with actin, AATF, BACE1, SPSB1, SPSB2 AND SPSB4. Component of a ternary complex composed of SQSTM1 and PRKCZ.

Function:

Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1.

Subcellular Location:

Cytoplasm Nucleus Mainly cytoplasmic in absence of apoptosis signal and in normal cells. Nuclear in most cancer cell lines. Nuclear entry seems to be essential but not sufficient for apoptosis. Nuclear localization includes nucleoplasm and PML nuclear bodies.

Protein Attributes:

Sequence length:

332

Sequence:

50:

100:

150:

200:

250:

300:

332:

LLNRDLDDME | DENEQLKQEN | KTLLKVVGQL | TR

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Rn.9127

String:

Q62627

STRING:

10116.ENSRNOP00000008222

KEGG:

rno:64513

Uniprot:

Q62627

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ELISA Kit for Rat PRKC apoptosis WT1 regulator protein

Cat.:

E15496h

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96T

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ELISA Kit for Rat PRKC apoptosis WT1 regulator protein

Cat.:

E15496m

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96T

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ELISA Kit for Rat PRKC apoptosis WT1 regulator protein

Cat.:

E15496r

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96T

CLIA Kit for Rat PRKC apoptosis WT1 regulator protein

Cat.:

U15496m

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Packing:

96T

CLIA Kit for Rat PRKC apoptosis WT1 regulator protein

Cat.:

U15496r

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MSDS:

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Packing:

96T

CLIA Kit for Rat PRKC apoptosis WT1 regulator protein

Cat.:

U15496h

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MSDS:

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Packing:

96T

Polyclonal Antibody for Rat PRKC apoptosis WT1 regulator protein

Cat.:

P15496Rb-r

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40ug/0.2ml

Polyclonal Antibody for Rat PRKC apoptosis WT1 regulator protein

Cat.:

P15496Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat PRKC apoptosis WT1 regulator protein

Cat.:

P15496Rb-h

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Packing:

40ug/0.2ml

Monoclonal Antibody for Rat PRKC apoptosis WT1 regulator protein

Protein for Rat PRKC apoptosis WT1 regulator protein

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Commonality of the gene programs induced by effectors of apoptosis in androgen-dependent and -independent prostate cells."
Sells S.F. , Wood D.P. Jr. , Joshi-Barve S.S. , Muthukumar S. , Jacob R.J. , Crist S.A. , Humphreys S. , Rangnekar V.M.
Cell Growth Differ.5:457-466(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];INDUCTION
tissue: Prostate.
2.

"Identification of a unique core domain of par-4 sufficient for selective apoptosis induction in cancer cells."
El-Guendy N. , Zhao Y. , Gurumurthy S. , Burikhanov R. , Rangnekar V.M.
Mol. Cell. Biol.23:5516-5525(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DOMAIN SAC;MUTAGENESIS;SUBCELLULAR LOCATION
3.

"Phosphorylation of Par-4 by protein kinase A is critical for apoptosis."
Gurumurthy S. , Goswami A. , Vasudevan K.M. , Rangnekar V.M.
Mol. Cell. Biol.25:1146-1161(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-155 BY PKA
4.

"Binding of Par-4 to the actin cytoskeleton is essential for Par-4/Dlk-mediated apoptosis."
Vetterkind S. , Illenberger S. , Kubicek J. , Boosen M. , Appel S. , Naim H.Y. , Scheidtmann K.H. , Preuss U.
Exp. Cell Res.305:392-408(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ACTIN

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